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How Adversity Shapes Health & Why It's Not In Your Head

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#4 Stress During Pregnancy, Birth and Infancy Increases Risk for Chronic Illness (Type 1 Diabetes, Asthma, ME/CFS)

Veronique Mead, MD, MA · September 29, 2017 · 2 Comments

#4 The Discovery Series. Stress in pregnancy, birth and infancy alter genes to affect risk for chronic illness such as #type1diabetes, #asthma, #ME/CFS, #MS and more. A recap
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The research presented in the past 3 posts taught me that adversity, trauma and stress during pregnancy as well as during birth and infancy increase risk for chronic illness such as type 1 diabetes and asthma. And that my mother and I had experienced similarly stressful events.

This post summarizes findings I’ve described in the past 3 posts. I refer to these early risk factors as adverse babyhood experiences (ABEs), building on the increasingly recognized research on adverse childhood experiences (ACEs) and their impact on long-term health.

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Download my free Book 4, which includes all 5 posts in this discovery series describing how adverse babyhood experiences (ABEs) affect risk for asthma, autoimmune diseases such as type 1 diabetes and other chronic illnesses.

I learned that distress during this early period of our lives and the separation of mothers and babies at birth affects risk for other chronic diseases too. These include high blood pressure and cholesterol, obesity, insulin resistance and type 2 diabetes. Collectively these are referred to as the metabolic syndrome or “Syndrome X” (see Fetal Origins of Adult Disease and my post about the cell danger response).

While such a finding can seem overwhelming for parents since stress during pregnancy is impossible to avoid and is such a normal part of life these days, the new understanding is more specific about the nature of these stressors.

It offers tools for identifying such events as well as for working with them. This new awareness also provides insights for prevention and treatment, including for parents as well as children, even months or years after they occur.

The discoveries suggested that the same kinds of events in my own prenatal life, birth and infancy were risk factors for my asthma, which started when I was 5 or 6 years old and continued into adulthood, although in a milder form.

These findings made me wonder whether my early experiences could have also affected my risk of developing ME/CFS (myalgic encephalitis / chronic fatigue syndrome), which didn’t start until I was in my 30s.

I eventually came across a study suggesting that stress during pregnancy and other early events might indeed play a role in risk for chronic fatigue syndrome (Dietert, 2008).

Perhaps the most life-changing insight in my initial explorations of the research, however, was that helping mothers heal from the effects of these rarely recognized adverse life events improved and often cured their children’s asthma (Madrid, 2005).

This was especially true when children were less than 9 years old.

It made me wonder whether similar treatment could improve, cure or prevent type 1 diabetes in kids given that they had the same kinds of risk factors.

Or whether similar approaches could help adults with T1D, asthma or other chronic illnesses, myself included.

 Stress during pregnancy birth and infancy increase risk for chronic illness and offer insights for healing these effects, which can improve or cure asthma in kids. Can such treatment improve, cure or prevent other chronic diseases such as my ME/CFS? Or T1D? A look at the research

I eventually came across research suggesting a fascinating explanation for how early risk factors for chronic illness appear to exert their effects – as well as a potential insight into how treating a mom can help her child’s asthma.

Research in the field of epigenetics is showing us that maternal experiences and behaviors alter her baby’s genes (here’s one of my favorite articles about this finding, by journalist Dan Hurley in Discover magazine, June 2015, who also has type 1 diabetes).

It wasn’t the genes themselves that changed as a result of life experiences however. It was the way genes functioned.

The particular genes identified made babies more sensitive to stress. In other words, early adverse experiences and other environmental stressors increased perceptions of threat in a baby’s nervous system.

It turned out that such changes can last a lifetime.

And they can affect a mother’s grandchildren and great grandchildren.

Interestingly, the study Dan Hurley described also showed that epigenetic changes, which stem from chemicals that attach to genes and alter their expression, can sometimes be removed.

This is what I suspect happened with Tony Madrid’s work with moms and the effect on their kids. Stressful events changed mothers’ natural capacities to feel love and bond with their babies. This affected the health, genes and physiology of their babies. When mothers healed, the effects of their recoveries reversed these changes in their children.

More research has emerged since my own first discoveries.

Pediatrician Jack Shonkoff, Director of Harvard’s Center on the Developing Child, writes eloquently about how there is now strong scientific consensus that early experiences interact with our biology, genes and physiology to shape long-term health and that epigenetics is helping make sense of these new perspectives (1)Shonkoff, J. P., et al. (2012). “The lifelong effects of early childhood adversity and toxic stress.” Pediatrics 129(1): e232-246; p. 235.

Metabolics researcher Dr. Robert Naviaux, MD, PhD, has described the cell danger response (CDR), showing that an accumulation of effects from environmental stressors can prolong this normally short-lived survival strategy to cause disease. Adverse events, including infections, can trigger CDRs. Exposures that affect risk for disease begin early in life during development. They include environmental stress during pregnancy as well as around the time of birth, in infancy, and during childhood. I’ve introduced the CDR and written about Naviaux’ study on ME/CFS as an example of how it drives disease.

Upcoming Posts: Are Stress and Trauma in Childhood Potential Risk Factors for Chronic Illness?

Stress and trauma are risk factors for chronic illness such as type 1 diabetes. The research is similar for other diseases such as #IBD #crohn’s #ulcerativeColitis #asthma #MS and more.

The research showing that stress during pregnancy, birth and infancy increases risk for chronic illness offers a wealth of potential for prevention, treatment and manage of chronic diseases of all kinds.

From what I learned about early risk factors for chronic disease, I wondered whether I, like the little rat pups in Michael Meaney and Moshe Szyf et al’s study described by Dan Hurley in Discover, had internalized perceptions of threat that were affecting my health.

Maybe I, too, was experiencing the effects of early life events and altered genes as risk factors for my chronic fatigue syndrome.

Given what Tony Madrid had discovered and then reproduced in his asthma studies, I wondered whether I could heal as well. Even though I’m an adult.

I decided to work with my health from these perspectives and to continue my research explorations.

I found another set of intriguing studies in type 1 diabetes as I scoured the stacks for the articles presented in the initial posts of the series.

Some of these studies were looking at whether serious life events in childhood are a risk factor for type 1 diabetes.

In the next part of the series I’ll share what I learned next. And I’ll tell you what it taught me about events from my own childhood that could have contributed further to my risk for ME/CFS and that I’d never considered to be anything other than normal.

Want to read about these early risk factors for chronic illness from the beginning? Here’s the intro post about type 1 diabetes, and post 2 on asthma. Post 3 describes how early life events affect genes. For an overview of what I learned in the past 15+ years here’s a summary.  Or you can download my free ebook overview. My personal story gives you an idea of what I’ve learned and how it makes sense of my chronic illness. If you’re thinking about working with symptoms from these perspectives here’s a list of therapies.

Related Posts:

Post 1: What Causes Type 1 Diabetes and Chronic Illness? Risk Factors in Pregnancy, Birth & Infancy

Post 2: How Early Life Experiences Affect Risk for Asthma and Offer Tools for Treatment and Prevention 

Post 3: Early Trauma and Epigenetics Make Sense of Chronic Disease (and Healing)

Epigenetics: Why Chronic Illness may be Reversible

How Understanding Trauma is Making Sense of My Chronic Fatigue (ME/CFS) and Helping Me Heal

Adverse Babyhood Experiences and Chronic Illness 1.0: A Subset of ACEs (Free ABE Fact Sheets & Checklist)

References[+]

↑1Shonkoff, J. P., et al. (2012). “The lifelong effects of early childhood adversity and toxic stress.” Pediatrics 129(1): e232-246; p. 235
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Chronic Illnesses, How Trauma Shapes Disease ABEs (Adverse Babyhood Experiences), Asthma, Diabetes, How Understanding Trauma Makes Sense of Chronic Illness Series

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Comments

  1. geekwire says

    January 16, 2019 at 10:00 pm

    Hi, I desire to subscribe for this webpage to get newest updates, so where can i do it please assist.

    Reply
    • Veronique Mead, MD, MA says

      January 27, 2019 at 9:12 am

      Hi,

      Your question about how to subscribe was in my spam folder and I only just saw it today. Here’s a page where you can subscribe to Chronic Illness Trauma Studies.

      Reply

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About Me

Hello! I'm Veronique Mead. On my blog I look at how chronic illness may be a natural response to one or more overwhelming experiences of threat. While this includes infections and toxins, I specialize in the role of psychological and physical trauma. Because the research - still overlooked and underestimated by medicine - has knocked my socks off.

 

Symptoms, it is turning out, may not be caused by mistakes our bodies are making but because our nervous systems have gotten stuck in states of fight, flight or freeze. Our bodies are our best friends and risk everything to help us survive. We are designed to recover or at least begin to heal from the effects of those survival strategies. I never knew any of this as a family physician or assistant professor. And it’s not in your head.

 

I've been testing these ideas with my own disabling disease for the past 20 years (I am much improved and get a little better every year). I share the research, challenges, why some things that seem so logical do not work for everyone (or make things worse), as well as my favorite 11 tools. This is so you can explore what might help you stabilize, improve or possibly even begin to reverse underlying drivers of your chronic illness too. For an overview with links to my most important posts, start here.

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